The Role of Food Supplementation in Microcirculation—A Comprehensive Review

Dele Raheem, Antonio Raposo, Ariana Saraiva, Fernando Ramos, Conrado Carrascosa, Rita Barbara, Henrique Silva

Research output: Contribution to journalReview Articlepeer-review

10 Citations (Scopus)
40 Downloads (Pure)


(1) Background: Cardiovascular disease (CVD) is a major public health concern worldwide and a key cause of morbidity and mortality in developed countries. Accumulating evidence shows that several CVD forms are characterized by significant microcirculatory dysfunction, which may both cause and be caused by macrovascular disease, often preceding clinical manifestations by several years. Therefore, interest in exploring food supplements to prevent and restore microcirculation has grown. Given the continuous need to expand the available therapeutic arsenal for CVD, the food supplements market has recently grown and is expected to continue growing. (2) Methods: We provide an authoritative up-to-date comprehensive review of the impact of food supplementation on microcirculation by analyzing the European and American legal food supplements framework and the importance of food safety/food quality in this industry. We review the main literature about food bioactive compounds with a focus on microcirculation and some main food supplements with proven benefits. (3) Results: Despite a lack of scientific evidence, diet and microcirculatory function are clearly connected. The main food supplement examples in the literature with potential beneficial effects on microcirculation are: Ruscus aculeatus L., Centella asiatica L., Ginkgo biloba L., Salvia miltiorrhiza Bunge, Crataegus spp., Ginseng, Mangifera indica L., Aesculus hippocastanum L., Hamamelis virginiana L., and Vitis vinifera L. (4) Conclusions: Further clinical trials are necessary to better explore the effects of these food supplements.
Original languageEnglish
Article number616
Pages (from-to)1-27
Issue number7
Publication statusPublished - 2 Jul 2021
MoEC publication typeA2 Review article in a scientific journal


  • cardiovascular; food quality; food safety; food supplements; microcirculation; nutrition
  • Microcirculation
  • Nutrition
  • Cardiovascular
  • Food supplements
  • Food safety
  • Food quality

Field of science

  • Plant biology, microbiology, virology


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